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目的了解目前乙型肝炎病毒(HBV)宫内感染情况,评价孕晚期注射HBIG预防HBV宫内感染效果。方法选取2006年10月~2008年1月在济南市妇幼保健院住院的符合纳入标准的318名血清HBsAg阳性孕妇及其分娩的324名新生儿进行HBV感染流行病学调查。结果 HBsAg阳性孕妇分娩的新生儿HBV宫内感染率为17.59%(57/324),其中孕晚期注射HBIG的HBsAg阳性孕妇分娩的新生儿HBV宫内感染率为9.76%(16/164),孕晚期未注射HBIG的HBsAg阳性孕妇分娩的新生儿宫内感染率为25.63%(41/160),差异有统计学意义(χ2=14.07,P<0.01)。结论孕晚期注射HBIG能有效阻断HBV宫内感染。
Objective To understand the current intrauterine infection of hepatitis B virus (HBV) and evaluate the effect of intrauterine infection in preventing HBV intrauterine infection by HBIG injection in the third trimester of pregnancy. Methods A total of 318 serum HBsAg-positive pregnant women and 324 newborns delivered in Ji’nan Women’s and Children’s Hospital from October 2006 to January 2008 were enrolled in this study. Results The intrauterine infection rate of newborns with HBsAg positive pregnant women was 17.59% (57/324). The intrauterine infection rate of HBsAg positive pregnant women who delivered HBIG in the third trimester of pregnancy was 9.76% (16/164) The rate of neonatal intrauterine infection in HBsAg-positive pregnant women without advanced HBIG was 25.63% (41/160), the difference was statistically significant (χ2 = 14.07, P <0.01). Conclusion Intrauterine injection of HBIG can effectively block HBV intrauterine infection.