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采取双盲(两不知)的追溯分析,对头颈部鳞癌病人的区域淋巴结进行切片检查,从组织形态上估计其免疫反应型。凡淋巴结有免疫刺激迹象者,其5年存活率较之无免疫刺激者显著增高。凡淋巴结显示淋巴球衰竭型者,病人无一可存活5年。肿瘤的分期或组织学分级并不影响上述关系。病人的淋巴结显示有免疫活性者,发生转移者较多。这些结果支持以下概念,即免疫功能为宿主抗癌的重要防御机能。所以,对区域淋巴结组织方面免疫活性的估计,为预测存活的重要参数。
Double-blind (two unknown) retrospective analysis of head and neck squamous cell carcinoma of the patient’s regional lymph nodes biopsy, from the histological evaluation of the immune response type. Where lymph nodes have signs of immune irritation, the 5-year survival rate was significantly higher than those without immune stimuli. Where the lymph nodes showed lymphoid failure type, none of the patients can survive for 5 years. Tumor staging or histological grade does not affect the above relationship. The patient’s lymph nodes showed immunocompetence who had more metastases. These results support the notion that immune function is an important defense against host cancer. Therefore, the assessment of regional lymph node tissue immunocompetence is an important parameter for predicting survival.