Pictures of focal nodular hyperplasia and hepatocellular adenomas

• 作 者: Christine Sempoux Charles Balabaud Paulette Bioulac-Sage
• 机 构: Service d’Anatomie Pathologique, Cliniques universitaires Saint Luc, Université catholique de Louvai
• 出 处: World Journal of Hepatology
• 发表日期: 2014年08期
• 关键词: nodular adenoma nodule nodules specimen hepatectomy histology atypical illustrat

This practical atlas aims to help liver and non liver pa-thologists to recognize benign hepatocellular nodules on resected specimen. Macroscopic and microscopic views together with immunohistochemical stains illustrate typical and atypical aspects of focal nodular hyperplasia and of hepatocellular adenoma, including hepatocel-lular adenomas subtypes with references to clinical and imaging data. Each step is important to make a correct diagnosis. The specimen including the nodule and the non-tumoral liver should be sliced, photographed and all different looking areas adequately sampled for par-affin inclusion. Routine histology includes HE, trichrome and cytokeratin 7. Immunohistochemistry includes glu-tamine synthase and according to the above results ad-ditional markers such as liver fatty acid binding protein, C reactive protein and beta catenin may be realized to differentiate focal nodular hyperplasia from hepatocel-lular adenoma subtypes. Clues for differential diagnosis and pitfalls are explained and illustrated.

This practical atlas aims to help liver and non liver pa-thologists to recognize benign hepatocellular nodules on resected specimens. Macroscopic and microscopic views together with immunohistochemical stains illustrate typical and atypical aspects of focal nodular hyperplasia and of hepatocellular adenoma, including hepatocel-lular adenomas subtypes with references to clinical and imaging data. Each specimen is important to make a correct diagnosis. The specimen including the nodule and the non-tumoral liver should be sliced, photographed and all different different looking areas adequately sampled for par- affin inclusion. HE, trichrome and cytokeratin 7. Immunohistochemistry includes glu-tamine synthase and according to the above results ad-ditional markers such as liver fatty acid binding protein, C reactive protein and beta catenin may be to differentiate focal nodular hyperplasia from hepatocel- lular adenoma subtypes. Clues for differential diagnosis and pitfa lls are explained and illustrated.