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慢性特发性血小板减少性紫癜(ITP)的发病机理还不清楚。目前,治疗多趋向于抑制对外周血小板的免疫反应,用得最多的药物为糖皮质激素,但部份病人血小板计数增高不显著。最近,Imbach等人报告用大剂量免疫球蛋白治疗儿童急、慢性ITP,血小板计数明显增加。作者报告静脉注射大剂量免疫球蛋白治疗成人慢性ITP的临床效果。 9例慢性ITP(3男,6女),1例系统性红斑狼疮(SLE)伴血小板减少。患者均符合以下条件:1.血小板低于10万长达1年以上,2.血小板计数变动的范围低于基础血小板计数的25%,3.有时有出血趋向,4.
The pathogenesis of chronic idiopathic thrombocytopenic purpura (ITP) is unclear. At present, the treatment tends to inhibit the immune response to peripheral platelets, the most used drug for glucocorticoid, but some patients did not increase platelet count was significant. Recently, Imbach et al reported that with high-dose immunoglobulin in children with acute and chronic ITP, platelet count was significantly increased. The authors report the clinical efficacy of intravenous bolus immunoglobulin in the treatment of adult chronic ITP. 9 cases of chronic ITP (3 males and 6 females) and 1 case of systemic lupus erythematosus (SLE) with thrombocytopenia. Patients are eligible for the following conditions: 1. Platelets less than 100,000 for up to 1 year or more, 2. The range of platelet count changes below 25% of the basal platelet count, 3. Bleeding tendency sometimes,