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目的探讨抗Ⅱ型胶原(抗-CⅡ)抗体检测在类风湿关节炎(RA)诊治中的应用价值。方法用ELISA方法检测RA患者(RA组,158例)、强直性脊柱炎(AS组,67例)患者和124例正常人(HC组)血清抗-CⅡ抗体含量。抗-CⅡ抗体阳性RA患者63例中有21例经治疗后随访2个月,比较治疗前后血清抗-CⅡ抗体含量。结果 RA组患者血清抗-CⅡ抗体含量高于HC组和AS组[(111.80±3.10)AU/ml vs.(20.10±0.90)AU/ml和(7.20±0.50)AU/ml](P<0.05),抗-CⅡ抗体阳性患者血清类风湿因子(RF)和血沉(ESR)较抗-CⅡ抗体阴性患者升高(P<0.05);RA患者经治疗后抗-CⅡ抗体下降(P<0.05)。结论抗-CⅡ抗体可作为RA的辅助诊断和监测疗效的指标。
Objective To investigate the diagnostic value of anti-type Ⅱ collagen (anti-C Ⅱ) antibody in the diagnosis and treatment of rheumatoid arthritis (RA). Methods Serum anti-CⅡ antibody levels in RA patients (RA group, 158 cases), ankylosing spondylitis (AS group, 67 cases) and 124 normal subjects (HC group) were detected by ELISA. Anti-C Ⅱ antibody-positive RA patients in 63 cases of 21 cases were followed up for 2 months after treatment, before and after treatment compared serum anti-C Ⅱ antibody levels. Results The level of anti-CⅡ antibody in RA patients was significantly higher than that in HC and AS patients [(111.80 ± 3.10) AU / ml vs. (20.10 ± 0.90) AU / ml and (7.20 ± 0.50) AU / ml] (P <0.05). The anti-CⅡ antibody positive patients had higher serum rheumatoid factor (RF) and ESR than anti-CⅡ antibody negative patients (P <0.05) . Conclusion Anti-CⅡ antibody can be used as an auxiliary diagnostic and monitoring indicators of RA.