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二膦酸盐是用以治疗各种骨代谢性疾病的一组药物,已开始用于治疗畸形性骨炎、骨肿瘤等骨破坏性疾病,但其治疗骨质疏松的历史很短。二膦酸盐不仅能抑制绝经后骨质疏松症的骨丧失,而且能增加骨量。当二膦酸盐与骨矿物质结合后能阻止矿物质晶体的生长,使许多二膦酸盐在大剂量时能阻滞矿化。应用于人体,当etidronate口服剂量超过800mg/d时能抑制正常的或异位的骨矿化。许多二膦酸盐能抑制骨吸收,这种抑制作用的机理是细胞性的。一般认为是通过对破骨细胞的直接抑制而达到抑制骨吸收的作用。在骨溶解过程中,破骨细胞
Bisphosphonates, a group of drugs used to treat various metabolic diseases of bone, have been used to treat bone-destructive diseases such as osteitis deformans and bone tumors. However, bisphosphonates have a short history of treatment of osteoporosis. Bisphosphonates not only inhibit bone loss in postmenopausal osteoporosis but also increase bone mass. When bisphosphonates bind to bone minerals, they prevent the growth of mineral crystals and allow many bisphosphonates to block mineralization at high doses. Applied to the human body, when etidronate oral dose exceeds 800mg / d can inhibit normal or ectopic bone mineralization. Many bisphosphonates inhibit bone resorption. The mechanism of this inhibition is cellular. Is generally believed that through the direct inhibition of osteoclasts and inhibit the role of bone resorption. In osteolysis, osteoclasts