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目的:探讨氟伐他汀联合前列环素(PGI_2)对糖尿病肾病合并高脂血症动静脉内瘘血栓形成的防治作用。方法:将糖尿病肾病合并高脂血症并行动静脉内瘘成形术21例患者作为观察组采用氟伐他汀联合PGI_2治疗,以另21例做采用常规治疗办法的患者作为对照组,对比凝血功能、血脂指标及肾功能、肝功能改善情况。结果:观察组的凝血功能、血脂指标及肾功能、肝功能改善情况明显优于对照组(P<0.05)。结论:氟伐他汀联合PGI_2能预防合并高脂血症糖尿病肾病患者动静脉内瘘血栓形成,提高糖尿病肾病透析患者的生存质量,为预防动静脉内瘘失功提供可靠的临床依据,减轻患者痛苦及经济负担。
Objective: To investigate the preventive and therapeutic effect of fluvastatin combined with prostacyclin (PGI_2) on thrombosis of diabetic nephropathy with arterial-venous fistula of hyperlipemia. Methods: Twenty-one patients with diabetic nephropathy complicated with hyperlipidemia and arteriovenous fistula were treated with fluvastatin combined with PGI 2, and 21 patients with conventional therapy were used as control group. Compared with coagulation function, Blood lipid indicators and renal function, improve liver function. Results: The improvement of coagulation, blood lipid, renal function and liver function in the observation group was significantly better than that in the control group (P <0.05). Conclusion: Fluvastatin combined with PGI_2 can prevent thrombosis of arteriovenous fistula in patients with diabetic nephropathy with hyperlipidemia and improve the quality of life in dialysis patients with diabetic nephropathy, and provide a reliable clinical basis for preventing the failure of arteriovenous fistula and relieving the suffering of patients And economic burden.