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亚急性重型肝炎和慢性活动性重型肝炎40例按性别、年龄、诊断、病程及病情轻重表现相似者匹配成20对,计亚急性重型肝炎6对(男5对,女1对),慢性活动性重型肝炎14对(男11对,女3对);分成A、B两组各20例。两组主要检验数值分别为:SB平均335.2μmol/L和309.5μmol/L,血清白蛋白平均34.7g/L和34.5g/L,血清球蛋白平均31.7g/L和37.6g/L,凝血酶原时间平均28.4s和29.7s,TTT平均12.8U和12.2U,ZnTT平均15.1U和15.2U,ALT平均536U(Reitman法)和459U。伴腹水者A组10例,B组11例。所有病例均以对症和支持疗法。各组均有15例以ACTH25U/d静滴。A组加用秋水仙碱1mg/d分2次口服,并逐步减少激素用量直至撤除。A组治愈15例,好转2例,死亡3例。B组治愈8例,好转2例,死亡10例。两组有效率(治愈+好转)或病死率相比较,均有显著差别(P=0.018)。结果证明秋水仙碱对亚急性重型肝炎或慢性活动性重型肝炎均有良好疗效,明显优于常规疗法和加用激素治疗者。
Subacute severe hepatitis and chronic active 40 cases of severe hepatitis by sex, age, diagnosis, duration of disease and severity of similarities and matched matched 20 pairs, accounting for 6 pairs of sub-acute severe hepatitis (male 5 pairs, 1 female), chronic activity 14 pairs of severe hepatitis (male 11 pairs, female 3 pairs); divided into A, B two groups of 20 cases. The main test values were 335.2μmol / L and 309.5μmol / L for SB, 34.7g / L for serum albumin, 34.5g / L for serum albumin, 31.7g / L for serum globulin and 37.6g / L for serum respectively. Thrombin The original time average 28.4s and 29.7s, TTT average 12.8U and 12.2U, ZnTT average 15.1U and 15.2U, ALT average 536U (Reitman method) and 459U. A group with ascites 10 cases, B group 11 cases. All cases were symptomatic and supportive therapies. 15 patients in each group with ACTH25U / d intravenous infusion. A group plus colchicine 1mg / d 2 times orally, and gradually reduce the amount of hormone until removed. A group of 15 cases were cured, improved in 2 cases, 3 patients died. B group cured 8 cases, improved in 2 cases, 10 cases died. There was a significant difference between the two groups in efficacy (cure + improvement) or mortality (P = 0.018). The results show that colchicine has a good effect on sub-acute severe hepatitis or chronic active hepatitis, which is obviously superior to conventional therapy and hormone therapy.