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采用放射免疫法和ＥＬＩＳＡ法测定了６９ 例高脂血症患者６ － 酮－ 前列腺素Ｆ１α（６ － Ｋ－ ＰＧＦ１α） 、血栓素Ｂ２（ＴＸＢ２） 以及Ｄ－ 二聚体（Ｄ－ ｄｉｍｅｒ） 和纤维蛋白（ 原） 降解产物（ＦＤＰ） ，并与２０ 例正常人比较。结果发现高脂血症患者６ － Ｋ－ ＰＧＦ１α低于对照组（ Ｐ＜ ０－０５） ，ＴＸＢ２ 高于对照组（ Ｐ＜０－０１） 。同时，Ｄ－ ｄｉｍｅｒ 和ＦＤＰ也高于对照组（ Ｐ＜ ０－００１） 。高脂血症患者体内处于ＰＧＩ２／ＴＸＡ２ 平衡失调、高凝状态和继发性纤溶亢进，对高脂血症患者定期监测体内凝血和纤溶功能有助于防治动脉粥样硬化。
The levels of 6 - K - PGF1α, TXB2, D - dimer and fibrin in 69 patients with hyperlipidemia were measured by radioimmunoassay and ELISA. Protein (original) degradation products (FDP), and compared with 20 normal subjects. The results showed that 6 - K - PGF1α in hyperlipidemic patients was lower than that in control group (P <0-05), TXB2 was higher than that in control group (P <0-01). At the same time, D-dimer and FDP were also higher than those in the control group (P <0-001). In patients with hyperlipidemia in PGI2 / TXA2 balance disorders, hypercoagulable state and secondary fibrinolysis, hyperlipidemia in patients with regular monitoring of coagulation and fibrinolysis help prevent atherosclerosis.