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酚妥拉明治疗难治性慢性肺心病５３例芮城县人民医院（０４４６００）李勤英我院１９８７年１月～１９９３年２月，用酚妥拉明治疗难治性慢性肺心病５３例收到满意疗效。资料与方法一、临床资料：诊断均符合１９８３年全国肺心病会议制定的慢性肺心病诊断标准。男３３例，女２０例，年龄３８～８７岁，病程３～３６年。二、治疗方法：５３例入院后均经抗生素、解痉、止喘、吸氧、强心利尿、纠正酸硷平衡等治疗无明显好转情况下，加用酚妥拉明静脉点滴，剂量１０～２０ｍｇ加入１０％葡萄糖液２５０ｍｌ中静脉滴注。每日一次，７～１０天为一个疗程。病情危重者可用酚妥拉明５ｍｇ加入５０％葡萄糖４０ｍｌ静脉缓慢注射，３０分钟给完。用药期间密切监测血压，根据血压调整滴速。一般以０．０５～０．ｌｍｇ／分滴速给药。给药期间还要监测心率、呼吸、肺部罗音、颈静脉怒张、肝脏大小压痛等。结果按下列标准评价疗效：①显效：心悸、胸闷、气急缓解，肺部罗音消失，肝脏缩小和压痛消失，肝颈返流征阴性，能下床活动。②有效：心悸、胸闷、气急减轻、肺部罗音减少、肝脏缩小和压痛减轻，水肿基本消退，能下床短暂活动。③无效：心衰症状无改善或见加重。治疗结果：显效２９例，有效１７例，无效６例，总
Phentolamine treatment of refractory chronic pulmonary heart disease in 53 cases Ruicheng County People’s Hospital (044600) Li Qinying our hospital from January 1987 to February 1993, with phentolamine refractory chronic pulmonary heart disease received 53 cases Satisfactory efficacy. Materials and Methods A, clinical data: diagnosis are in line with the National Conference of Cor Pulmonary in 1983 developed a diagnostic criteria for chronic pulmonary heart disease. 33 males and 20 females, aged 38 to 87 years, duration of 3 to 36 years. Second, the treatment: 53 cases were admitted to the hospital after antibiotics, antispasmodic, Zhichuan, oxygen, cardiac diuretic, correct acid-base balance and other treatment did not significantly improve the case, plus intravenous infusion of phentolamine dose of 10 ~ 20mg added 10% glucose solution 250ml intravenous infusion. Once daily, 7 to 10 days for a course of treatment. In critical condition available phentolamine 5mg added 50% glucose 40ml intravenous slow injection, 30 minutes to finish. Closely monitor blood pressure during treatment and adjust drip rate based on blood pressure. Generally 0.05 to 0. lmg / min drip rate. Also monitor the heart rate during the administration, breathing, pulmonary rales, jugular vein engorgement, tenderness and other liver size. The results were evaluated according to the following criteria: ① markedly effective: palpitations, chest tightness, shortness of breath, lung rales disappeared, the liver shrinks and tenderness disappear, liver reflux sign negative, can get out of bed activity. ② effective: heart palpitations, chest tightness, shortness of breath to reduce lung rales reduced to reduce the liver and tenderness, edema subsided, able to get out of bed transient activities. ③ invalid: no improvement in heart failure symptoms or see increased. Treatment outcome: effective in 29 cases, effective in 17 cases, 6 cases, total