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从人外周血中分离出树突状细胞,体外观察了其对LAK细胞活性的影响。发现:5×102~1×104/ml树突状细胞对LAK细胞活性起增强作用,而5×104~1×105/ml树突状细胞却抑制LAK杀伤活性。这说明人外周血树突状细胞对LAK细胞活性起双相性调节作用。
Dendritic cells were isolated from human peripheral blood and their effects on LAK cell activity were observed in vitro. The results showed that 5 × 102 ~ 1 × 104 / ml dendritic cells could enhance the activity of LAK cells, while 5 × 104 ~ 1 × 105 / ml dendritic cells inhibited LAK activity. This shows that human peripheral blood dendritic cells play a biphasic role in LAK cell activity.