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1葡萄糖毒性高血糖毒性作用通常是指长期高血糖对全身各组织的不良影响,从而导致一系列的并发症。高血糖对胰岛细胞的毒性作用曾受到高度关注,也是高血糖水平与细胞水平损害间联系的研究热点。β细胞分泌调控的主要生理决定因素是血糖浓度,胰岛β细胞对葡萄糖变化产生应答呈“类S型”关系,当血糖<5mmo/L对β细胞几乎无刺激作用,随着血糖逐渐升高而胰岛素分泌速率加快,血糖浓度达到8mmol/L达最大半数刺激值,血糖超过
1 glucose toxicity Hyperglycemic toxicity is usually refers to the long-term high blood sugar on the body’s various tissues adverse effects, leading to a series of complications. The toxic effects of hyperglycemia on islet cells have received great attention and are also the focus of research on the relationship between hyperglycemia and cell damage. β-cell secretion is the main physiological determinants of blood glucose concentration, pancreatic β-cell response to glucose changes were “S-type” relationship, when the blood glucose <5mmo / L on the beta cells almost no stimulating effect, with the gradual rise in blood glucose High and insulin secretion rate, blood glucose concentration reached 8mmol / L up to half the maximum stimulation, blood glucose more than