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目的:探讨术前外周血中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、单核细胞与淋巴细胞比值(MLR)、预后营养指数(PNI)等炎症标志物与乙肝病毒(HBV)相关原发性肝癌患者根治性切除术后预后的关系.方法:回顾性分析接受根治性切除术的331例HBV相关原发性肝癌患者的临床及随访资料,计算NLR、PLR、MLR、PNI值.采用Kaplan-Meier法和Cox回归分析影响患者生存的因素.结果:NLR、PLR、MLR、PNI的界值分别为2.41、106.80、0.24、45.根据界值将患者分为高低两组.多因素分析显示,门静脉癌栓、术前AFP、AST、肝内播散及NLR是影响HBV相关原发性肝癌患者根治术后生存的独立危险因素,HR(95％ CI)分别为2.652(1.863 ～3.776)、1.476(1.027 ～2.120)、1.437(1.047～1.972)、1.596(1.065 ～2.390)和1.563(1.077 ～2.268),PNI是此类患者术后生存的保护因素,HR(95％ CI)为0.657(0.468 ～0.922)(P均＜0.05).结论:术前NLR及PNI与HBV相关原发性肝癌患者术后生存有关,低NLR及高PNI的患者预后较好.“,”Aim:To explore the prognostic value of pre-operative neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),monocyte to lymphocyte ratio (MLR),prognostic nutritional index (PNI) in hepatitis B virus (HBV)-related hepatocellular carcinoma(HCC) after radical operation.Methods:A total of 331 HCC patients who had been undergone radical operation were followed up.The clinical and laboratory data of the patients were collected.The values of NLR,PLR,MLR,and PNI were calculated.Kaplan-Meier and Cox regression were used to analyze the risk factors.Results:The optimal cutoff levels of NLR,PLR,MLR and PNI were 2.41,106.80,0.24 and 45,respectively.The patients were allocated into two groups according to the cutoff levels.Multivariate analysis revealed that PVTT,pre-operative AFP,AST,intrahepatic metastasis,NLR and PNI were independent predictors of overall survival for HCC after hepatectomy,andHR(95％CI) were 2.652(1.863-3.776),1.476(1.027-2.120),1.437(1.047-1.972),1.596(1.065-2.390),1.563 (1.077-2.268),and 0.657 (0.468-0.922) (P ＜ 0.05).Conclusion:Pre-operative NLR and PNI were independent predictors of overall survival for HBV-related HCC after hepatectomy.The patients with low NLR and high PNI indicate better prognosis.