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目的:探讨新生儿高胆红素血症患儿血β2微球蛋白变化对临床诊断的意义。方法:对2012年7月~2013年7月经临床确诊的300例新生儿高胆红素血症患儿血清中β2微球蛋白含量进行测定,并与正常新生儿血清中β2微球蛋白含量进行对比分析。结果:新生患儿血清内β2微球蛋白含量与其肾功能异常率、病症严重程度呈正相关。结论:针对新生儿高胆红素血症患儿早期诊断中进行血清内β2微球蛋白含量测定,对判定患儿肾功能异常有较为明显的指导作用。
Objective: To investigate the clinical significance of serum β2-microglobulin in children with neonatal hyperbilirubinemia. Methods: Serum β2-microglobulin levels in 300 neonates with hyperbilirubinemia diagnosed from July 2012 to July 2013 were measured and compared with that of normal neonates Comparative analysis. Results: Serum levels of β2-microglobulin in neonates were positively correlated with the abnormal renal function and the severity of the disease. Conclusion: The determination of serum β2-microglobulin in early diagnosis of neonatal hyperbilirubinaemia may play an important guiding role in determining the renal dysfunction in children.