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目的观察奥美拉唑对老年患者应用非甾体抗炎药引起胃黏膜损伤的预防作用。方法选择服用非甾体抗炎药的老年患者64例,随机分为对照组34例,奥美拉唑组30例。对照组均单独服用非甾体抗炎药,奥美拉唑组在应用非甾体抗炎药治疗的基础上,口服奥美拉唑每日20mg。4周后对患者上消化道症状及上消化道出血的发生率进行比较。结果对照组消化道出血发生率为11.8%,奥美拉唑组未见消化道出血,两组比较差别显著(P<0.05)。对照组上消化道症状发生率为17.6%,奥美拉唑组出现上消化道症状的为13.4%,两组比较无显著差别(P>0.05)。结论老年患者在应用非甾体抗炎药过程中预防性应用奥美拉唑,能减轻消化道症状、预防消化道出血的发生。
Objective To observe the preventive effect of omeprazole on gastric mucosal injury induced by NSAIDs in elderly patients. Methods Sixty-four elderly patients who took NSAIDs were randomly divided into control group (n = 34) and omeprazole group (n = 30). The control group were taking non-steroidal anti-inflammatory drugs alone, omeprazole group in the application of non-steroidal anti-inflammatory drugs based on the treatment of oral omeprazole daily 20mg. Four weeks later, the incidence of upper gastrointestinal symptoms and upper gastrointestinal bleeding were compared. Results The incidence of gastrointestinal bleeding was 11.8% in the control group and no gastrointestinal bleeding was found in the omeprazole group. There was significant difference between the two groups (P <0.05). The incidence of upper gastrointestinal symptoms was 17.6% in the control group and 13.4% in the omeprazole group. There was no significant difference between the two groups (P> 0.05). Conclusion The prophylactic application of omeprazole in the elderly patients in the application of non-steroidal anti-inflammatory drugs can reduce gastrointestinal symptoms and prevent the occurrence of gastrointestinal bleeding.