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目的:探讨糖化血红蛋白(HbA1c)、空腹血糖(FPG)与2型糖尿病患者视网膜病变(DR)的相关性。方法:对我院2010年1月-2012年12月住院或门诊的336例2型糖尿病(T2DM)患者进行眼底检查或眼底血管荧光素造影检测,按有无视网膜病变分为视网膜病变(DR)组和无视网膜病变(NDR)组,并对HbA1c、FBG水平进行检测。结果:DR组较NDR组HbA1c水平高,差异有统计学意义(P<0.05),HbA1c水平和DR分期呈正相关(r=0.526,P<0.001),而DR组和NDR组FPG水平差异无无统计学意义(P>0.05)。结论:可将HbA1c作为2型糖尿病患者视网膜病变发生和发展的监测指标之一。
Objective: To investigate the relationship between HbA1c, fasting plasma glucose (FPG) and retinopathy (DR) in type 2 diabetic patients. Methods: 336 patients with type 2 diabetes mellitus (T2DM) hospitalized or outpatient from January 2010 to December 2012 in our hospital were examined by fundus examination or fundus fluorescein angiography. According to the presence or absence of retinopathy, the patients were divided into retinopathy (DR) Group and no retinopathy (NDR) group, and HbA1c, FBG levels were detected. Results: The levels of HbA1c in DR group were significantly higher than those in NDR group (P <0.05). There was a positive correlation between HbA1c level and DR stage (r = 0.526, P <0.001) Statistical significance (P> 0.05). Conclusion: HbA1c can be used as one of the surveillance indicators for the occurrence and development of retinopathy in type 2 diabetic patients.