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报道358例慢性肝病血清。α─L岩藻糖苷酶(AFU)的测定结果。结果表明AFU对原发性肝癌(PHC)的阳性率为74.5%,假阳性率为11.6%。慢性活动性肝炎组阳性率达25.6%,该组AFU明显高于PHC组以外的其他各组(P<0.01).认为AFU对PHC的诊断的确有重要意义,但由于假阳性相对较高,特异性相对较低,使其诊断价值受一定限制。本文讨论了肝炎和PHC时AFU升高的可能机理。
358 cases of chronic liver disease were reported. α-L fucosidase (AFU) determination results. The results showed that the positive rate of AFU in primary liver cancer (PHC) was 74.5%, and the false positive rate was 11.6%. The positive rate of chronic active hepatitis group was 25.6%. AFU in this group was significantly higher than other groups except PHC group (P<0.01). It is considered that AFU has important significance in the diagnosis of PHC, but due to its relatively high false positive rate and relatively low specificity, its diagnostic value is limited. This article discusses the possible mechanisms of elevated AFU in hepatitis and PHC.