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本文报告应用临床分离的细菌进行肝素抗菌作用研究的情况,并对其作用机制给予估计。作者利用近期从临床分离到的8种细菌(每种选10个菌株),以含不同浓度肝素(0.31～400u/ml)的心脑浸液肉汤进行培养。结果发现肝素对大肠杆菌,金黄色葡萄球菌,表皮葡萄球菌,绿脓杆菌,以及白色念珠菌均有不同程度的抑制作用,然而对肺炎杆菌,产气杆菌,柠檬酸杆菌却无抑制作用。实验表明:肝素抑菌作用因菌株而异,且受培养基浓度和钙镁离子的影响。在肝素浓度为125—500u/ml时,10株金黄色葡
This article reports the use of clinically isolated bacteria for heparin antibacterial effects of the study, and its mechanism of action given. The authors used the eight clinically isolated bacteria (10 strains of each strain) to be cultured in cardiomyocyte broth containing different concentrations of heparin (0.31-400 u / ml). The results showed that heparin inhibited Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa and Candida albicans to a certain extent, however, it did not inhibit Klebsiella pneumoniae, Aerobacter aerogenes and Citrobacter. Experiments show that: heparin antibacterial effect due to different strains, and the concentration of the medium and the impact of calcium and magnesium ions. In the heparin concentration of 125-500u / ml, 10 golden yellow