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目的探讨美蓝染色法哨兵淋巴结测图技术在非小细胞肺癌手术中应用的可行性和价值。方法选取35例手术治疗的非小细胞肺癌患者,术中在肿瘤周围注射美蓝并寻找哨兵淋巴结,检验哨兵淋巴结检出率及其预测区域淋巴结是否转移的敏感性和特异性。结果35例患者中共有32例(91%)检测到哨兵淋巴结。15例患者哨兵淋巴结无转移,其他淋巴结亦未发现转移。哨兵淋巴结位于纵隔3例。结论美蓝染色法哨兵淋巴结测图技术在非小细胞肺癌手术中的应用是可行的;哨兵淋巴结预测区域淋巴结转移情况的特异性很高,如果哨兵淋巴结无转移,可以准确预测区域淋巴结无转移。
Objective To investigate the feasibility and value of using methylene blue staining for sentinel lymph node mapping in non-small cell lung cancer surgery. Methods 35 cases of non-small cell lung cancer patients undergoing surgery were selected. Intraoperative injection of methylene blue and looking for sentinel lymph node in the tumor were performed to test the detection rate of sentinel lymph node and the sensitivity and specificity of predicting regional lymph node metastasis. Results Sentinel lymph nodes were detected in 32 of 35 patients (91%). Fifteen patients had no metastasis from sentinel lymph node and no metastasis from other lymph nodes. Sentinel lymph nodes in the mediastinum in 3 cases. Conclusion Sentinel lymph node mapping technique using methylene blue staining is feasible in non-small cell lung cancer surgery. Sentinel lymph node prediction is of high specificity in regional lymph node metastasis. If there is no metastasis of sentinel lymph node, it can accurately predict regional lymph node metastasis.