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采用放射免疫测定方法 (RIA) ,观察 4 3例糖尿病患者血、尿 α1-微球蛋白 (α1- MG)、β2 -微球蛋白 (β2 - MG)及血肌酐 (SCr)变化。结果显示 :常规尿蛋白阴性 ,SCr含量异常者占 2 5.5% ,尿中 α1- MG/ Cr、β2 - MG/ Cr、血 α1- MG、β2 - MG异常者分别占 79.0 7%、6 7.4 4 %、37.2 1%、55.81%。各种微球蛋白测定的阳性率与 SCr比较 ,差异有显著性 (P<0 .0 0 5)。结果说明血、尿 α1- MG、β2 -MG在诊断糖尿病早期肾损伤中有一定的临床意义。并提示血尿α1- MG、β2 - MG测定在反映肾脏损伤中比 SCr敏感
Radioimmunoassay (RIA) was used to observe the changes of blood and urine α1 - microglobulin (α1 - MG), β2 - microglobulin (β2 - MG) and serum creatinine (SCr) in 43 diabetic patients. The results showed that the common urinary protein was negative and the content of SCr was abnormal in 2 5.5%. The urinary α1 - MG / Cr, β2 - MG / Cr, blood α1 - MG and β2 - MG were 79.0 7% and 6 7.44 respectively %, 37.2 1%, 55.81%. The positive rates of various microglobulin assays were significantly different from those of SCr (P <0.05). The results show that blood, urine α1-MG, β2-MG in the diagnosis of early diabetic renal injury has some clinical significance. And prompted hematuria α1-MG, β2 - MG assay in reflecting the renal damage than SCr-sensitive