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目的探讨肺炎支原体肺炎喘息患儿血清IL-5水平的变化,探讨IL-5在肺炎支原体感染发病机制中的作用及意义。方法纳入研究对象分组,肺炎支原体肺炎伴喘息患儿20例为观察组,肺炎支原体肺炎无喘息患儿20例为无喘息组,非肺炎支原体肺炎无喘息20例为对照组。观察组和无喘息组血清MP-IgM定性检测均为阳性。采用ELISA方法检测每组患儿血清IL-5水平,对数据进行统计分析。结果观察组、无喘息组、对照组依次为:血清IL-5(ng/L):45.89±12.65,36.25±9.86,27.53±8.45。观察组与无喘息组、观察组与对照组血清IL-5水平差异均有统计学意义(P<0.05),无喘息组与对照组血清IL-5水平比较差异有统计学意义(P<0.05)。结论肺炎支原体肺炎伴喘息患儿血清IL-5水平有着显著变化,IL-5水平升高在肺炎支原体肺炎患儿喘息的发生、发展中有重要作用。
Objective To investigate the changes of serum IL-5 in patients with pneumonia mycoplasma pneumonia and to explore the role and significance of IL-5 in the pathogenesis of Mycoplasma pneumoniae infection. Methods Twenty patients with mycoplasma pneumoniae pneumonia and wheezing were included in the study group. 20 patients without pneumonia and 40 patients with pneumonia without pneumonia were without asthmatic group, and 20 patients with non-pneumoniae mycoplasma pneumonia without asthma as control group. Serum MP-IgM in the observation group and non-wheezing group were both qualitatively detected. ELISA method was used to detect serum IL-5 levels in each group, and the data were statistically analyzed. Results The observation group, no wheezing group, the control group followed by: serum IL-5 (ng / L): 45.89 ± 12.65,36.25 ± 9.86,27.53 ± 8.45. There was significant difference in serum IL-5 levels between the observation group and the non-asthmatic group, the observation group and the control group (P <0.05), the difference of serum IL-5 level between the non-asthmatic group and the control group was statistically significant (P <0.05 ). Conclusion The serum level of IL-5 in patients with Mycoplasma pneumoniae pneumonia and wheezing has significant changes. Elevated IL-5 level plays an important role in the occurrence and development of asthma in children with Mycoplasma pneumoniae pneumonia.