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幽门螺杆菌是一种全球范围内的慢性感染性致病菌,除导致慢性胃炎、消化性溃疡、胃癌等胃肠疾病外,还与慢性心血管疾病,肝脏及胆道疾病密切相关。研究表明,其基因结构多态性差异是导致不同临床表现的主要原因,近年来对Hp毒力因子及其基因多态性研究取得长足进展,本文对其主要的毒力基因多态性及可能的致病机制进行综述。
Helicobacter pylori is a chronic infection of the global pathogenic bacteria, in addition to lead to chronic gastritis, peptic ulcer, stomach cancer and other gastrointestinal diseases, but also with chronic cardiovascular disease, liver and biliary tract diseases are closely related. Studies have shown that the genetic polymorphism is the main reason leading to different clinical manifestations. In recent years, great progress has been made in the study of Hp virulence factors and their genetic polymorphisms. In this paper, the main virulence gene polymorphisms and possible The pathogenesis is reviewed.