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目的通过诊断试验Meta分析,综合评价抗环瓜氨酸肽抗体(CCP)和类风湿因子(RF)联合诊断类风湿关节炎(RA)的效果。方法通过检索万方、维普、CNKI等数据库,获得有关抗CCP和RF联合诊断RA的文献,提取相关数据;采用SAS 8.02进行诊断试验Meta分析。结果抗CCP/RF并联的准确度为0.803,诊断优势比为16.590;抗CCP+RF串联的准确度为0.841,诊断优势比为27.781;两种联合诊断准确度比较,差异无统计学意义(P>0.05)。结论抗CCP和RF联合诊断效果较好,并联能够提高灵敏度,串联能够提高特异度,联合诊断对RA具有较高的诊断价值。
Objective To evaluate the combined effect of anti-cyclic citrullinated peptide antibody (CCP) and rheumatoid factor (RF) in the diagnosis of rheumatoid arthritis (RA) by diagnostic test meta-analysis. Methods The databases of Wanfang, VIP, CNKI and other databases were searched to get the literature about anti-CCP and RF combined diagnosis of RA, and the relevant data were extracted. SAS 8.02 was used for meta-analysis of diagnostic tests. Results The accuracy of anti-CCP / RF parallelism was 0.803 and the diagnostic odds ratio was 16.590. The accuracy of anti-CCP + RF tandem was 0.841 and the diagnostic odds ratio was 27.781. There was no significant difference between the two methods > 0.05). Conclusions The combination of anti-CCP and RF is effective in diagnosis, and the sensitivity in parallel can be increased. The series can increase the specificity, and the combined diagnosis of RA has a higher diagnostic value.