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由于 LPO 水平随增龄而升高,天然抗氧化剂 SOD 活性等随增龄而下降,LPO 与 SOD 水平已被用作研究衰老的常用指标。本文采用 SOD/LPO比值作为反映人和实验动物体内自由基反应(过氧化系统)与抗氧化两系统问关系的指标,观测了不同年龄组健康成人及不同月龄组正常大鼠红细胞 SOD/LPO 值的变化和补充外源 DNA 对这一指标的影响。结果表明:老龄组人和大鼠红细胞 LPO 水平较青年组明显升高,SOD 活性则较青年组降低,SOD/LPO值显著下降;老龄组人及大鼠补充 DNA 制剂后,SOD/LPO 值明显回升;表明外源 DNA 在动物体内能提高红细胞的 SOD/LPO 值,提示 DNA 抗衰老的作用机制之一可能是它的抗氧化作用。DNA 在国外是热门抗衰老制剂,它对老龄者体内核酸、蛋白质等代谢的影响值得深入研究。
As LPO levels increase with age, the natural antioxidant SOD activity decreases with age, and LPO and SOD levels have been used as common indicators for the study of aging. In this paper, the ratio of SOD/LPO was used as an indicator to reflect the relationship between free radical reaction (peroxidation system) and antioxidant system in human and experimental animals. The red cell SOD/LPO was observed in healthy adults and rats of different age groups at different ages. Changes in value and the effect of supplemental exogenous DNA on this indicator. The results showed that the LPO levels of red blood cells in elderly people and rats were significantly higher than those in the young group, SOD activity was lower than that in the young group, and the SOD/LPO value was significantly decreased; SOD/LPO values were significantly increased in the aged group and rats after supplementing with DNA preparations. The rebound indicates that exogenous DNA can increase the SOD/LPO values of red blood cells in animals, suggesting that one of the mechanisms of DNA anti-aging may be its anti-oxidation effect. DNA is a popular anti-aging agent in foreign countries. Its influence on the metabolism of nucleic acids and proteins in elderly people deserves further study.