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本文报告青藤碱对麻醉犬和免在位肠管的影响.静脉注射青藤碱引起小肠暂时兴奋,这种兴奋作用可被笨海拉明、六烃季胺完全阻断,阿托品完全或部分阻断,但切断两侧迷走神经不能阻断.给犬静脉注射青藤碱,可使胃分泌和酸度增加,胃蛋白酶活性无明显改变.青藤碱在兴奋肠管同时使血浆组织胺含量和淋巴形成增加,皮肤组织胺含量下降.以上结果表明青藤碱引起胃肠道兴奋的主要原因,系青藤碱释放组织胺的结果.
This article reports the sinomenine on anesthetized dogs and the role in the bowel-free administration of intravenous injection of sinomenine temporarily caused by the small intestine, this excitement can be stupid Hyalin, hexatriquat completely blocked, atropine completely or partially blocked Off, but cut off both sides of the vagus nerve can not be blocked to the dog intravenous injection of sinomenine, can increase gastric secretion and acidity, pepsin activity was no significant change in the sinomenine in the bowel while plasma histamine levels and lymph formation increased , The histamine content of the skin decreased.The above results show that sinomenine cause the main reason of gastrointestinal excitability, the Department of sinomenine release of histamine results.