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目的:观察桃红四物汤防治奥沙利铂所致神经毒性的临床疗效。方法:将73例消化系统癌症患者随机分为2组,2组按病种和病理类型制定并实施含奥沙利铂的联合化疗,治疗组37例化疗前及化疗后使用桃红四物汤,对照组36例化疗前后不使用中药干预;观察2组患者神经毒性发生情况。结果:神经毒性总发生率治疗组为13.5%,对照组为55.6%,2组比较,差异有非常显著性意义(P<0.01)。结论:桃红四物汤防治奥沙利铂所致神经毒性具有一定的疗效。
Objective: To observe the clinical efficacy of Taohong Siwu decoction in preventing and treating neurotoxicity induced by oxaliplatin. Methods: Seventy-three patients with digestive system cancer were randomly divided into two groups. Two groups were given oxaliplatin combined with chemotherapy according to disease type and pathological type. 37 patients in the treatment group were treated with Taohong Siwu Decoction before chemotherapy and after chemotherapy, The control group 36 patients before and after chemotherapy did not use Chinese medicine intervention; observed two groups of patients with neurotoxicity. Results: The total incidence of neurotoxicity was 13.5% in the treatment group and 55.6% in the control group. There was significant difference between the two groups (P <0.01). Conclusion: Taohong Siwu decoction can prevent neurotoxicity induced by oxaliplatin.