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测定了193名健康儿童血清总胆固醇及载脂蛋白 B(APOB)的含量。其中有冠心病家族史61名(祖父或外祖父母己明确诊断冠心病者),无家族史者132名。结果表明:家族史对儿童血清总胆固醇含量无明显影响,而 APOB 水平则有升高趋势,其升高百分率明显高于无家族史者。并讨论了 APOB 水平与冠心病发病的关系,同时预测有家族史儿童冠心病潜在发病的可能性较高。
193 healthy children were measured serum total cholesterol and apolipoprotein B (APOB) content. Among them, 61 have a family history of coronary heart disease (grandfather or grandparent has a definite diagnosis of coronary heart disease), 132 without family history. The results showed that: the family history had no significant effect on serum total cholesterol, while the level of APOB had an increasing trend, and the percentage of increase was significantly higher than that of no family history. The relationship between the level of APOB and the incidence of coronary heart disease was also discussed. At the same time, it is highly probable to predict the potential incidence of coronary heart disease in children with family history.