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小鼠腹腔注射（0．1ml／10g）：①热板法，分异丙酚、阿芬太尼、异丙酚＋阿芬太尼3组，观察异丙酚对阿芬太尼镇痛作用的影响。②异丙酚与不同剂量阿芬太尼复合，以小鼠翻正反射消失及恢复时间，观察阿芬太尼对异丙酚入睡率、睡眠潜伏期和持续期的影响。③序贯法测定小鼠异丙酚（i．v）及异丙酚＋阿芬太尼的半数致死置（LD50），观察两药合用时对异丙酚LD50的影响。结果：异丙酚能使阿芬太尼的阈下镇痛量出现镇痛效应（P＜0．01）；阿芬太尼对异丙酚的入睡率、睡眠潜伏期和持续期无明显影响（P＞0．05），但大剂量可延长异丙酚的睡眠时间（P＜0．01）；两药合用时对异丙酚的LD50无明显影响（P＞0．05）。结论；两药伍用镇痛好，且不明显延长苏醒时间（大剂量阿芬太尼除外），安全可靠。
Mice were injected intraperitoneally (0.1ml / 10g): ① hot plate method, divided into propofol, alfentanil, propofol + alfentanil group 3, to observe the analgesic effect of propofol on alfentanil Impact. ② Propofol was combined with different doses of alfentanil to observe the disappearance and recovery time of normal reflex in mice and the effect of alfentanil on propofol sleep rate, sleep latency and duration. ③ Sequential method was used to determine the median lethal dose (LD50) of propofol (i.v) and propofol + alfentanil in mice. The effects of propofol and LD50 on the LD50 were observed. RESULTS: Propofol was able to induce analgesic effects on subthreshold analgesia of alfentanil (P <0.01). Alfentanil had no effect on the rate of falling asleep, sleep latency and duration of propofol P> 0.05). However, high dose prolonged the sleep time of propofol (P <0.01). No significant effect was found on LD50 of propofol when used in combination (P> 0.05). Conclusion; Both drugs with good analgesic, and did not significantly extend the recovery time (high-dose alfentanil excluded), safe and reliable.