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目的:探讨重度慢性心力衰竭患者血浆B型尿钠肽(BNP)的改变及临床意义。方法:选择我院2009年3月-2011年3月收治的重度慢性心力衰竭患者58例,其中心功能III级25例,IV级33例,同期健康体检者30例,测定血清BNP浓度、左室射血分数(LVEF),对两组进行比较分析。结果:重度慢性心力衰竭患者血浆BNP水平较正常对照组明显增高(P<0.01),并随心功能恶化,血浆BNP水平升高,LVEF下降。抗心力衰竭药物综合治疗后,血浆BNP水平明显降低(P<0.05)。结论:血浆BNP水平的检测可作为临床判断心衰的有效指标,对心衰的预后有重要的意义。
Objective: To investigate the changes of plasma B-type natriuretic peptide (BNP) in patients with severe chronic heart failure and its clinical significance. Methods: Fifty-eight patients with severe chronic heart failure admitted to our hospital from March 2009 to March 2011 were selected. Among them, there were 25 patients with grade III function, 33 patients with grade IV, and 30 patients with healthy grade 30 at the same period. Serum BNP concentration, Room ejection fraction (LVEF), comparative analysis of the two groups. Results: Plasma BNP level in patients with severe chronic heart failure was significantly higher than that in the normal control group (P <0.01). With the deterioration of cardiac function, plasma BNP level and LVEF decreased. Plasma BNP levels decreased significantly after treatment with anti-heart failure drugs (P <0.05). Conclusion: The detection of plasma BNP levels can be used as an effective indicator of clinical judgment of heart failure, which is of great significance to the prognosis of heart failure.