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本文的目的是探索抗绿脓(?)菌抗体(Fab’)_2片对实验性绿脓杆菌角膜炎的疗效。实验所用动物为Lewis大鼠,体重200～250克。每个角膜接种一滴培养过夜的绿脓杆菌培养液。接种后将动物分成5组,组1为对照组,不给以任何治疗,其余4组为实验组,在不同时间(接种前或接种后),以不同方式(点眼,结膜下注射,或肌注)给药。结果表明:实验组和对照组有统计学的差异(P<0.01),但实验组之间即不同途径不同时间给药,差异不显著(P>0.05),本文还介绍了抗绿脓杆菌抗体(Fab’)_2片的制备方法。
The purpose of this article is to investigate the efficacy of anti-Pseudomonas aeruginosa antibody (Fab ’) 2 on experimental Pseudomonas aeruginosa keratitis. Animals used in the experiment were Lewis rats weighing 200 to 250 grams. One drop of P. aeruginosa culture fluid was inoculated per cornea overnight. Animals were divided into 5 groups after inoculation, group 1 as a control group, without any treatment, and the remaining 4 groups as experimental groups, at different times (before inoculation or after inoculation), in different ways (ophthalmia, subconjunctival injection, Note) Administration. The results showed that there was a significant difference between the experimental group and the control group (P <0.01), but there was no significant difference (P> 0.05) between the experimental group and different routes at different times (P> 0.05). The anti-Pseudomonas aeruginosa antibody (Fab ’) _ 2 tablet preparation method.