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本文对1981－1995年间收治的2340例肺结核治疗中，抗结核药物致肝损害69例进行观察，共发生率为2．95％，黄殖发生率为0．64％；有肝病史75例中出现肝损害为14．67％，HBsAg（＋）110例为8．18％，有饮酒史220例为7．27％；轻度肝损害与59．42％，中度和重度者分别为31．88％和8．70％；RFP致肝损害与84．06％，iNH占8．70％，PAS占4，35％，PZA占2．90％，症状以恶心、呕吐、厌食、乏力等分别占75．36％、40．58％、47．83％、56．52％；ALT升高占96．65％。尽管本文资料偏低于文献报道，但仍可揭示：抗结核化疗前检肝功能很的必要；对于有肝病史、HBsAg（＋）和有饮酒史老用机结核药应密切监视；首次应用抗结核药出现肝损害反应时，恢复后不可再用。
In this paper, from 1981 to 1995, 2340 cases of pulmonary tuberculosis in the treatment of anti-TB drug-induced liver damage in 69 cases were observed, a total incidence of 2.95%, the incidence of yellowing was 0.64%; history of liver disease in 75 cases The incidence of liver damage was 14.67%, 110 cases of HBsAg (+) was 8.18%, drinking history of 220 cases was 7.27%; mild liver damage and 59.42%, moderate and severe were 31 .88% and 8.70% respectively. RFP caused liver damage with 84.06%, iNH accounted for 8.70%, PAS accounted for 4 and 35%, PZA accounted for 2.90%. The symptoms were nausea, vomiting, anorexia and fatigue Accounting for 75.36%, 40.58%, 47.83% and 56.52% respectively; the ALT increased 96.65%. Although the information in this article is lower than that reported in the literature, it is still possible to reveal that it is necessary to check liver function before anti-TB chemotherapy. For those with history of liver disease, HBsAg (+) and old TB drugs with drinking history should be closely monitored. Tuberculosis drugs appear when liver damage reaction, can not be reused after recovery.