Pathogenesis of Insulin Resistance and Atherogenic Dyslipidemia in Nonalcoholic Fatty Liver Disease

• 作 者: Daud H.Akhtar Umair Iqbal Luis Miguel Vazquez-Montesino Brittany B.Dennis Aijaz Ahmed
• 机 构: Department of Medicine,University of British Columbia Faculty of Medicine,Vancouver BC,Canada“,”Depa
• 出 处: 临床与转化肝病杂志（英文版）
• 发表日期: 2019年4期
• 关键词: Nonalcoholic fatty liver disease Insulin resistance Cardiovascular diseases Dysl

Nonalcoholic fatty liver disease(NAFLD)is the most common cause of chronic liver disease in the developed world,with a global prevalence of around 25％.NAFLD is considered to be the hepatic manifestation of metabolic syndrome and is strongly associated with obesity,insulin resistance and dysli-pidemia.Insulin resistance plays a pivotal role in the develop-ment of NAFLD-related dyslipidemia,which ultimately increases the risk of premature cardiovascular diseases,a leading cause of morbidity and mortality in patients with NAFLD.Insulin affects hepatic glucose and lipid metabolism by hepatic or extrahepatic pathways.Aside from insulin resistance,several other factors also contribute to the patho-genesis of atherogenic dyslipidemia in patients with NAFLD.These include diet composition,gut microbiota and genetic factors,to name a few.The identification of potentially modifiable risk factors of NAFLD is of importance,so as to target those who may benefit from lifestyle changes and to help develop targeted therapies that decrease the risk of cardiovascular diseases in patients with NAFLD.