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目的观察氨氯地平短期治疗非杓形高血压患者对异常血压昼夜节律与左心室舒张功能的逆转作用。方法２８例患者口服氨氯地平５～１０ｍｇ，１／ｄ，治疗前和疗程第６周时进行动态血压监测和超声心动图检查。结果２５例完成治疗随访的患者中，异常血压节律逆转１５例，未逆转１０例，逆转患者左心室舒张功能显著改善。结论氨氯地平治疗后，约６０％原发性高血压异常血压昼夜节律患者可改善血压昼夜节律。
Objective To observe the reversal effects of amlodipine on short-term treatment of non-dipper hypertensive patients with abnormal blood pressure circadian rhythm and left ventricular diastolic function. Methods 28 patients were treated with amlodipine 5 ~ 10mg, 1 / d, before treatment and at the 6th week of treatment. Ambulatory blood pressure monitoring and echocardiography were performed. Results Among the 25 patients who completed follow-up of treatment, abnormal blood pressure rhythm was reversed in 15 cases and no reversal in 10 cases. The left ventricular diastolic function was significantly improved in patients with reversal. Conclusion After amlodipine treatment, about 60% of patients with essential hypertension with abnormal blood pressure circadian rhythm can improve blood pressure circadian rhythm.