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三尖杉酯碱(H),高三尖杉酯碱(HH)和半合成三尖杉酯碱(PSH)有显著抗动物移植性肿瘤活性;临床应用表明,对非淋巴细胞性白血病有较好疗效。与大多数抗肿瘤药一样,主要副作用为骨髓抑制。为了评价这些药物的选择性如何,本文采用脾集落形成法和琼脂扩散盒方法,比较了H、HH、PSH、阿糖胞苷(Ara—a)和环磷酰胺(CP)对小鼠造血干细胞(NC FU—S),粒系定向干细胞(NCFU—C)和白血病干细胞(LCFU—S及LCFU—C)的作用。
The harringtonine (H), homoharringtonine (HH) and semi-synthetic harringtonine (PSH) have significant anti-transplantation tumor activity in animals; clinical application shows that it is better for non-lymphocytic leukemia Efficacy. As with most antineoplastic drugs, the main side effect is myelosuppression. In order to evaluate the selectivity of these drugs, the spleen colony formation method and the agar diffusion kit method were used to compare the hematopoietic stem cells of mice with H, HH, PSH, Ara-a, and cyclophosphamide (CP). (NC FU-S), Role of committed stem cell lines (NCFU-C) and leukemia stem cells (LCFU-S and LCFU-C).