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Klatt曾报导,以4-(对硝基苄基)吡啶用比色法则定血液中烃化剂的含量.关于此种显色剂的制备,文献中有关它的前体——4-苄基吡啶的合成方法报告较多.但反应产物都是2-与4-苄基吡啶混合物,必须经细致分离,而且收率亦低.Jerchel等报导4-氯代甲基吡咤盐酸盐与苯翘过Friedel-Crafts反应得到4-苄基吡啶,收率较高(75％).由于原料难得,因此作者设计了以异烟酸为原料的下列合成路线,所得4-苄基吡啶的总收率达51％.不仅不可能有化合物Ⅲ的异构体,而且原料易得,实验条件也较易控制.
Klatt has reported the use of 4- (p-nitrobenzyl) pyridine as a colorimetric method for determining the amount of alkylating agent in blood. For the preparation of such a color former, the literature regarding its precursor, 4-benzyl Pyridine synthesis method is more reported, but the reaction products are 2 - and 4 - benzyl pyridine mixture, must be carefully separated, and the yield is low.Jerchel et al reported 4-chloromethylpyridinium hydrochloride and benzene The yield of 4-benzylpyridine was higher (75%) due to the Friedel-Crafts reaction, and the author designed the following synthetic route using isonicotinic acid as starting material because of the rare starting materials. The total yield of 4-benzylpyridine Rate of 51%. Not only impossible to compound III isomers, and raw materials easily available, experimental conditions are easier to control.