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目的检测出血性脑梗死患者血清S100B蛋白水平动态变化,探讨S100B蛋白与出血性脑梗死的关系。方法应用酶联免疫双抗体夹心法(enzyme linked immunosorbent assay,ELISA)测定60例急性出血性脑梗死患者发病后24 h内,第3、5、7、14 d血清S100B蛋白水平,并与大面积脑梗死组、正常对照组进行对比。结果出血性脑梗死患者血清S100B蛋白水平在发病后24 h内开始升高,第3 d达到高峰,之后开始下降,出血性脑梗死患者发病后24 h内,第3、5、7、14 d的血清S100B蛋白水平均显著高于正常对照组(P<0.05),也高于大面积脑梗死组(P<0.05)。结论血清S100B蛋白水平早期升高可作为预测急性脑梗死患者继发出血的参考指标。
Objective To detect the serum level of S100B protein in patients with hemorrhagic cerebral infarction and to investigate the relationship between S100B protein and hemorrhagic cerebral infarction. Methods The levels of S100B protein in serum of 60 patients with acute hemorrhagic cerebral infarction within 24 hours after onset were detected by enzyme linked immunosorbent assay (ELISA) on the 3rd, 5th, 7th and 14th days, Cerebral infarction group, normal control group for comparison. Results Serum levels of S100B in patients with hemorrhagic cerebral infarction began to increase within 24 h after onset, peaked on the third day, and then began to decline. Within 24 h after onset of hemorrhagic cerebral infarction, Serum S100B protein levels were significantly higher than the normal control group (P <0.05), also higher than the large area cerebral infarction group (P <0.05). Conclusion The early increase of serum S100B protein level can be used as a reference index for predicting secondary hemorrhage in patients with acute cerebral infarction.