论文部分内容阅读
目的 :研究有机磷农药中毒毒物经胆道排泄的量化规律 ;疏肝利胆中药结合胆汁引流疗法对胆道排泄有机磷的影响及对血浆和门静脉血浆有机磷浓度与胆碱酯酶浓度的影响。方法 :将染毒动物分为传统治疗组(B组 )、胆汁引流组 (C组 )和疏肝利胆法结合胆汁引流组 (D组 ) ,染毒后按时动态测定对硫磷、对氧磷浓度 ,胆碱酯酶浓度 ;同时测定 C、D组动物胆汁对硫磷、对氧磷浓度 ;染毒 48小时测定门静脉血浆对硫磷、对氧磷浓度。结果 :有机磷农药中毒后确实存在胆道排毒过程 ,经疏肝利胆中药结合胆汁引流治疗组胆道排泄有机磷总量明显高于单纯胆汁引流组 ,前者血浆和门静脉对硫磷、对氧磷浓度明显低于后者 ,前者胆碱酯酶浓度明显高于后者 ,C、D组的治疗效果明显优于传统治疗组。结论 :疏肝利胆法结合胆汁引流可明显增加有机磷经胆道排泄 ,本治法为抢救有机磷农药中毒提供了一个新的治疗理论。
OBJECTIVE: To study the quantitative rules of organophosphorus pesticide poisoning through the biliary excretion, the effects of Shugan Lidan combined with bile drainage therapy on biliary excretion of organophosphorus and its effects on plasma and portal plasma organic phosphorus concentrations and cholinesterase concentrations. Methods: The animals were divided into the traditional treatment group (group B), bile drainage group (group C) and Shugan gallbladders combined with bile drainage group (group D) Phosphorus concentration and cholinesterase concentration were measured at the same time. The bile parathion and paraoxon concentrations in the animals in C and D groups were also measured. The concentrations of parathion and paraoxon in the portal venous plasma were measured 48 hours after exposure. Results: There was indeed biliary detoxification after organophosphorus pesticide poisoning. The total amount of organophosphorus excretion in the biliary tract was significantly higher than that in the simple biliary drainage group treated with Shugan Lidan combined with bile drainage. The former plasma and portal parathion and paraoxon concentrations Significantly lower than the latter, the former cholinesterase concentration was significantly higher than the latter, C, D group was significantly better than the traditional treatment group. Conclusion: Shugan gallbladder combined with bile drainage can significantly increase the excretion of organophosphorus through the biliary tract, the treatment method for the salvage of organophosphate pesticide poisoning provides a new therapeutic theory.