论文部分内容阅读
心房颤动是临床上较常见的一种心律失常,其发生机制尚未完全阐明.近年来随着对心房颤动的深入研究,认为C反应蛋白在心房颤动的发生和发展中起着重要的作用.C反应蛋白导致心房颤动的机制可能为:(1)C反应蛋白能激活经典补体途径,从而在心房颤动的触发和维持中起到直接的作用.C反应蛋白通过与受损细胞的磷脂组分的结合,抑制肌膜内囊泡中钠和钙离子的交换,引起心房的电重构,从而导致膜功能障碍和心律不齐的发展.(2)C反应蛋白作为典型的炎症标志物,提示心房中受损的心肌细胞发生炎症反应,使心房肌细胞变性、坏死,引起心房肌间质纤维化,并导致心房结构变化和心房重构,为心房颤动的发生和维持提供了结构基础.“,”Atrial fibrillation is one of the most common arrhythmias in clinical practice,however,its mechanism has not yet fully understood.Recent studies have shown that C-reactive protein plays an important role in the occurrence and development of atrial fibrillation. C-reactive protein causes atrial fibrillation may be:(1)C-reactive protein can activate the complement system,which plays an important role in the initiation and maintenance of atrial fibrillation.C-reactive protein can bind to the phospholipid component of the damaged cells,which can inhibit the exchange of sodium and calcium ions in the sarcoplasmic membrane of the sarcolemma.It can result in electrical remodeling of the atria,and prompt the development of membrane dysfunction and arrhythmia.(2)CRP is one of the typical inflammatory markers, suggesting that atrial damage in the heart of the cardiomyocytes,which can prompt the progress of the atrial fibrosis and result in the structural remodeling of the atria.It provides the substrate for the occurrence and maintenance of atrial fibrillation.