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目的:探讨慢性肾小球肾炎合并高血压患者应用缬沙坦治疗的效果。方法:回顾性分析122例合并高血压的慢性肾小球肾炎患者的临床资料,随机分为治疗组与对照组,治疗组60例,对照组62例,两组常规肾病治疗(休息,控制蛋白质、盐的摄入,必要时透析),治疗组应用缬沙坦控制血压,对照组应用贝那普利控制血压,疗程为24周。观察治疗前后的血压、心率、24h尿蛋白、内生肌酐清除率(CCr)、血清肌酐(SCr)及不良反应。结果:治疗组各指标明显优于对照组,具有统计学意义(P<0.05)。结论:缬沙坦对于合并高血压的慢性肾小球肾炎患者有着较好的降压及改善肾功能的作用,值得临床推广应用。
Objective: To investigate the effect of valsartan treatment in patients with chronic glomerulonephritis and hypertension. Methods: A retrospective analysis of 122 cases of chronic glomerulonephritis patients with hypertension clinical data were randomly divided into treatment group and control group, the treatment group of 60 patients, control group of 62 patients, two groups of conventional treatment of kidney disease (rest, control of protein , Salt intake, if necessary, dialysis), the treatment group valsartan control of blood pressure, the control group benazepril control of blood pressure, treatment for 24 weeks. Blood pressure, heart rate, 24h urine protein, creatinine clearance rate (CCr), serum creatinine (SCr) and adverse reactions were observed before and after treatment. Results: Each index of the treatment group was significantly better than that of the control group, with statistical significance (P <0.05). Conclusion: Valsartan has better antihypertensive effect and renal function in chronic glomerulonephritis patients with hypertension, which is worthy of clinical application.