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乙肝病毒宫内感染是发展成乙肝表面抗原 ( HBs Ag)慢性携带者重要原因之一 ,也是导致生后接种乙肝疫苗失败的主要原因 (1 ,2 )。国内外资料报告其宫内感染率高达 1 3%～44% (3～ 4)。我们对湖北省荆门市的孕妇乙肝病毒宫内感染进行调查 ,2 73名孕妇产前乙肝病毒感染标志表明 :HBs Ag阳性率为 9.98% ;抗 - HBe阳性率为 4.37% ;抗 - HBc阳性率为 5 .6 % ,HBs Ag,HBe Ag双阳性者为 6 .6 6 %。产后对婴儿随访半年以上 (分别在产后 2 4小时 ,产后 1月 ,产后 6月 )结果表明在双阳性母亲所生婴儿中 ,HBs Ag阳性率为 1 6 .6 7% ,而在单阳性母亲所生婴儿中 ,则无 1例是 HBs Ag阳性
Hepatitis B virus intrauterine infection is one of the important reasons for the development of chronic carriers of hepatitis B surface antigen (HBsAg), which is also the main reason for the failure of hepatitis B vaccine after birth (1, 2). Domestic and foreign information reported intrauterine infection rates as high as 13% to 44% (3 to 4). We investigated the intrauterine HBV infection of pregnant women in Jingmen City of Hubei Province. The markers of prenatal hepatitis B virus infection in 2 73 pregnant women showed that the positive rate of HBs Ag was 9.98%, the positive rate of anti-HBe was 4.37%, and the positive rate of anti-HBc Was 5.6%. The positive rate of HBsAg and HBeAg was 6.66%. Postpartum follow-up of infants more than six months (respectively, 24 hours postpartum, postpartum 1 month, postpartum 6 months) results showed that double positive mothers born infants, HBs Ag positive rate of 16.6%, while in single positive mothers None of the infants born was positive for HBs Ag