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近十余年来通过医学研究认识到维生素D必须经过代谢的交化后才发挥其生理效应和肾脏具有内分泌作用。体内形成的或由体外进入机体的维生素D须先在肝细胞的微粒体内转化为1,25-OH-D_3,经血液运输到达肾脏后,在皮质细胞内再经过酶的作用转交为1,25-(OH)_2-D_3,才对骨骼和小肠发挥作用。目前认为这是维生素D的活性代谢物质。1,25-(OH)_2-D_3的产生受血中PTH和肾脏皮质细胞内Pi浓度的影响。在维生素代谢和磷钙的调节中肾脏占有轴心的地位。可以将维生素D(25-OH-D_3)视为激素原,PTH的作用相当于肾脏的促激素,肾脏内形成的1,25-(OH)_2-D_3则可视为一种动员磷、钙的激素,肾脏本身为内分泌器官之一。
In the past decade or so, medical research has realized that vitamin D must exert its physiological effects and endocrine function in the kidney after being metabolized. In vivo formed or by the body into the body of the vitamin D must first liver cells in the microsomal transformation into 1,25-OH-D_3, reached by the blood transport to the kidneys, and then in the cortex through the role of enzyme and passed to 1,25 - (OH) _2-D_3, to play a role in the bones and small intestine. Now think it is the active metabolite of vitamin D. The production of 1,25- (OH) _2-D_3 is affected by PTH in blood and Pi concentration in renal cortical cells. The kidneys occupy a central axis in the regulation of vitamin metabolism and phospho-calcium. Vitamin D (25-OH-D_3) can be regarded as prohormone, PTH acts as a renal hormone, and 1,25- (OH) _2-D_3 formed in the kidney can be considered as a mobilization of phosphorus and calcium The hormones, the kidney itself is one of the endocrine organs.