“解心痛”煎剂对蟾蜍心室肌细胞电活动的影响

• 作 者: 郑宝灿
• 机 构: 山东大学生物系
• 出 处: 山东大学学报(自然科学版)
• 发表日期: 1982年02期
• 关键词: 心室肌细胞 动作电位 复极化 除极化 静息膜电位 抗心律失常 心肌细胞 灌流液 对抗作用 解剖显微镜

本文报告了以5%浓度的“解心痛”对心室肌细胞电活动参数的影响。经“解心痛”处理后的心室肌细胞,其静息膜电位基本保持原水平,动作电位振幅、0相最大除极化速率,膜反应性和传导性均下降,2相平台缩短,复极化速率减低,动作电位完全复极化时程缩短,而有效不应期反有延长。对“解心痛”抗心律失常的可能机制进行了讨论。

This article reports the effect of 5% concentration of “heartache” on electrical activity parameters of ventricular myocytes. The resting membrane potential of the ventricular myocytes treated with “relief pain” remained at the original level, the amplitude of the action potential, the maximum depolarization rate of the phase 0, the membrane reactivity and conductivity were all decreased, and the 2-phase platform was shortened. As the rate of chemical reduction is reduced, the time course of the action potential is fully repolarized is shortened, and the effective refractory period is prolonged. The possible mechanism of anti-arrhythmia for “solution heartache” was discussed.