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采用细胞毒理学方法，以大鼠游离肝细胞半数中毒浓度（ＴＣ５０）为观察指标，对镉、硒、铜、砷、锑、汞、锌、铅、铬、镍１０种金属及类金属组成２９个配对进行了联合毒性的研究。结果表明，１０种金属及类金属化合物肝细胞毒性大小顺序是汞＞镉＞铅＞砷＞锑＞铜＞铬＞镍＞锌＞硒，与体内肝毒性顺序基本一致。汞、镉、铅三种金属之间有增毒作用，对其它金属的毒性亦有增强作用。锌可以拮抗镉、铅的毒性作用，硒可以保护汞、砷对细胞的毒性，其余金属配对呈毒性相加作用。铬和砷对镉的细胞毒性表现为拮抗作用，其机理需要进一步进行研究。
Cytotoxicity was used to detect the concentration of free half-cells of hepatocytes (TC50) in rats. Ten kinds of metals and metalloids such as cadmium, selenium, copper, arsenic, antimony, mercury, zinc, lead, chromium and nickel Paired for a joint toxicity study. The results showed that the order of the hepatotoxicity of 10 kinds of metal and metalloid compounds was mercury> cadmium> lead> arsenic> antimony> copper> chromium> nickel> zinc> selenium, which was consistent with the order of hepatotoxicity in vivo. Mercury, cadmium, lead between the three kinds of metals have increased toxicity, toxicity to other metals also enhance the role. Zinc can antagonize the toxic effects of cadmium and lead, and selenium can protect the cells from toxic effects of mercury and arsenic, while the rest of the metals are toxic and additive. Chromium and arsenic show antagonistic effects on the cytotoxicity of cadmium, and its mechanism needs further study.