论文部分内容阅读
内皮素1表达增加引起内皮功能障碍和氧化应激。通常糖尿病患者体内的血浆内皮素1水平增加。鉴于糖尿病患者的内皮功能障碍常先于血管并发症,研究者假设在血管内皮细胞中,内皮素1的过度表达会加重糖尿病引起的血管内皮功能障碍。方法:对6周龄的雄性野生型小鼠和在内皮细胞中过度表达人
Increased endothelin 1 expression causes endothelial dysfunction and oxidative stress. In general, there is an increase in plasma endothelin 1 in diabetics. Given that endothelial dysfunction in diabetic patients often precedes vascular complications, the researchers hypothesized that endothelin-1 overexpression may aggravate diabetic-induced endothelial dysfunction in vascular endothelial cells. Methods: Six-week-old male wild-type mice and overexpressing human in endothelial cells