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目的初步观察鼓室内放置庆大霉素明胶海绵对顽固性梅尼埃病的疗效。方法选取经正规保守治疗无效、严重眩晕伴中～重度听力损失的顽固性梅尼埃病患者6例,采用鼓室内放置庆大霉素(30 mg/ml)明胶海绵的方法进行治疗。观察眩晕、听力及耳鸣的变化。结果4例患者一次治疗后眩晕完全控制,随访1～3年无复发。2例治疗后仍有眩晕,其中1例重复治疗1次后随访2年眩晕控制;另1例给予鼓室内地塞米松注射,眩晕发作较治疗前减轻。6例患者中,出现听力轻度恶化和一过性耳鸣加重各1例。结论鼓室内放置庆大霉素明胶海绵可能是一种治疗顽固性梅尼埃病安全、有效的新方法。
Objective To observe the effect of gentamicin gelatin sponge on refractory Meniere’s disease in a tympanic cavity. Methods Six patients with intractable Meniere’s disease who were treated with gentamicin gentamicin (30 mg / ml) by intragastric method were selected for treatment of patients with refractory or severe vertigo complicated with moderate to severe hearing loss. Observation of dizziness, hearing and tinnitus changes. Results Four patients had complete control of vertigo after one treatment, and no recurrence was observed in one to three years follow-up. 2 cases were still dizzy after treatment, 1 case of repeat treatment followed by 2 years of vertigo control; the other 1 case given intrathecal dexamethasone injection, vertigo attack than before treatment to reduce. Among the 6 patients, one case had mild hearing deterioration and one transient tinnitus aggravating. Conclusion The gentamicin gelatin sponge in the tympanic cavity may be a safe and effective new method for the treatment of refractory Meniere’s disease.