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本研究从分子水平研究血管通抗动脉粥样硬化的作用机制。实验用日本种雄性鹌鹑给予高脂饲料１２周，形成动脉粥样硬化后给予血管通３０天，取血用放射免疫法测定内皮素和降钙素基因相关肽，观察血管通对动脉粥样硬化模型血浆内皮素和降钙素基囚相关肽以及总胆固醇和甘油三酯的影响。结果表明：模型形成过程中，其血浆内皮素升高，降钙素基因相关肽降低，总胆固醇和甘油三酯明显升高；血管通可降低模型的血浆内皮素（Ｐ＜０．０５）及降低总胆固醇（Ｐ＜０．００１）和甘油三酯（Ｐ＜０．００１），升高其降钙素基固相关肽（Ｐ＜０．０５）。上述结果提示：血管通抗动脉粥样硬化机制可能与其通过降低血浆内皮素和升高降钙素基因相关肽有关。
This study investigated the mechanism of anti-atherosclerosis through the molecular level. The experiment was performed on a high-fat diet for 12 weeks with Japanese male fleas, and blood vessels were sterilized for 30 days after atherosclerosis was formed. Blood was taken for endothelin and calcitonin gene-related peptides by radioimmunoassay, and vascular permeability was observed for atherosclerosis. Model Plasma Endothelin and Calcitonin-related Prion-related Peptide and Total Cholesterol and Triglyceride Effects The results showed that in the process of model formation, plasma endothelin levels were elevated, calcitonin gene-related peptides were decreased, total cholesterol and triglycerides were significantly increased, and vascular permeability decreased the plasma endothelin level in the model (P<0.05). Lowered total cholesterol (P<0.001) and triglycerides (P<0.001), increased its calcitonin-based solid-related peptide (P<0.05). The above results suggest that the mechanism of vascular resistance to atherosclerosis may be related to its decrease in plasma endothelin and elevation of calcitonin gene-related peptides.