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以T细胞为作用靶子的单克隆抗体(McAb)对类风湿性关节炎有一定疗效,但是它的作用不能持久,这部分由于抗体免疫原性引起的治疗不足。将啮齿动物抗体转换成人源化McAb有可能解决这个问题。作者报道用人源化McAb治疗顽固性类风湿性关节炎的效果。研究对象为8例类风湿性关节炎患者,年龄32～69岁,血沉40～100mm/h,C反应蛋白(CRP)45～160mg。清晨均有关节僵硬
Monoclonal antibodies (McAbs) that target T cells have some effect on rheumatoid arthritis but its effect can not be sustained, partly due to inadequate treatment due to the immunogenicity of the antibody. Converting rodent antibodies to humanized McAbs may solve this problem. The authors report the effect of treatment of refractory rheumatoid arthritis with humanized McAbs. The subjects were 8 patients with rheumatoid arthritis, aged 32 to 69 years, erythrocyte sedimentation rate 40 to 100 mm / h and C-reactive protein (CRP) 45 to 160 mg. There are joints in the early morning stiffness