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目的:探讨64层螺旋CT胰腺灌注成像在胰腺癌诊断中的价值。方法:2008年9月～2009年6月,拟诊胰腺癌的患者26例,采用64层螺旋CT行胰腺灌注扫描,灌注扫描结束后进行常规胰腺双期扫描。动态增强图像用siemens body perfusion软件处理,分别测量肿瘤组织和周围残余正常胰腺组织的局部组织血流量(bloodflow,BF)、血容量(blood volume,BV)、峰值(PE)、渗透性(perme ability,P)和达峰时间(timetopeak,TTP)平均值,并进行统计分析。结果:20例灌注成功,其中手术病理证实的胰腺癌14例,其他病变6例。胰腺癌组织的BF、BV、PE均低于残余正常胰腺的测量值,差异有统计学意义(P<0.05)。胰腺癌与残余正常胰腺的渗透性(P)、达峰时间(TTP)测量值无统计学差异。结论:胰腺癌与残余正常胰腺的灌注参数差异对胰腺癌的诊断有一定价值。
Objective: To explore the value of 64-slice spiral CT pancreatic perfusion imaging in the diagnosis of pancreatic cancer. Methods: From September 2008 to June 2009, 26 patients with suspected pancreatic cancer underwent pancreatic perfusion scan with 64-slice spiral CT. After routine perfusion scan, routine pancreas dual-phase scan was performed. Dynamically enhanced images were processed with siemens body perfusion software to measure local blood flow (bloodflow, BF), blood volume (BV), peak (PE), and permeability (permelet) of tumor tissue and surrounding normal pancreatic tissue. , P) and time to peak (TTP) mean, and statistical analysis. Results: Twenty patients had successful perfusion, including 14 cases of pancreatic cancer confirmed by pathology, and 6 cases of other lesions. The BF, BV, and PE of pancreatic cancer tissues were lower than those of residual normal pancreas, and the difference was statistically significant (P<0.05). There was no statistical difference in permeability (P) and time to peak (TTP) measurements between pancreatic cancer and residual normal pancreas. Conclusion: The differences in perfusion parameters between pancreatic cancer and residual normal pancreas have a certain value in the diagnosis of pancreatic cancer.