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本文对71例成都地区汉族Graves病患者进行了Gm和Km因子的研究。与正常对照比较,疾病组Gm~(axg)和Gm~(afbg)表型频率明显升高,Gm~(afb)表型频率明显下降(P<0.01,比数比分别为4.95、2.84、0.365);两组的Km表型频率无明显差异。提示免疫遗传因素在Graves病的发病中起一定作用。
In this paper, Gm and Km factors were studied in 71 Han patients with Graves disease in Chengdu. Compared with the normal control group, the frequencies of Gm axg and Gm afbg phenotypes were significantly increased and the phenotype of Gm afb was significantly decreased (P <0.01, the odds ratios were 4.95, 2.84 and 0.355 ); There was no significant difference in Km phenotype between the two groups. Prompt immune genetic factors in the pathogenesis of Graves disease play a role.