Synthesis of New Ligand 1,2-Bis{di[(R,R)-1,3,2-oxzaphosphlidine]phosphino}ethane with C_2-symmetric

• 出 处: Chemical Research in Chinese Universities
• 发表日期: 2007年05期
• 关键词: ethane symmetric R R hydrogenation asymmetric alcohols catalyzed readily complex

New ligand 1,2-bis{di[(R,R)-1,3,2-oxzaphosphlidine]phosphino}ethane [(R,R)-BDOPPEs 1,2,3 and 4] with C2-symmetric axis and bearing nitrogen and oxygen were synthesized from readily available optically active amino alcohols.Rh complexes with these ligands were highly enantioselective catalysts for asymmetric hydrogenation of N-benzoyldehydroamino acid derivatives and α-functionalized ketones in 99%e.e.and 98%e.e.,respectively.This new class of(R,R)-BDOPPEs 1,2,3 and 4 gave much more effectivity and enantionselectivity than their corresponding non-C2-asymmetric aminophosphine phosphinite. New ligand 1,2-bis {di [(R, R) -1,3,2-oxazaphosphlidine] phosphino} ethane [(R, R) -BDOPPEs 1,2,3 and 4] with C2-symmetric axis and bearing nitrogen and oxygen were synthesized as readily available optically active amino alcohols. Rh complexes with these ligands were highly enantioselective catalysts for asymmetric hydrogenation of N-benzoyldehydroamino acid derivatives and α-functionalized ketones in 99% ee and 98% ee, respectively. This new class of (R, R) -BDOPPEs 1,2,3 and 4 gave much more effectivity and enantionlectivity than their corresponding non-C2-asymmetric aminophosphine phosphinite.